report. Further, Dr Xie made numerous Chinese language documents available in English. We also thank Dr Hongguang Dong, Geneva University Hospital, Switzerland for providing additional information. Appreciation is extended to the Norwegian Royal Ministry of Health and Social Affairs for providing the financial support to print this review. iii iv Contents Contents Acknowledgements ...............................................................................................iii Contents ........................................................................................................... v Introduction............................................................................................................ 1 Background........................................................................................................ 1 Objectives .......................................................................................................... 2 Use of the publication ........................................................................................ 2 1. General considerations .................................................................................. 3 1.1 Definition.................................................................................................. 3 1.2 Need for evaluation ................................................................................. 3 1.3 Evaluation methodology .......................................................................... 3 1.4 Safety ...................................................................................................... 5 1.5 Availability and practicability.................................................................... 5 1.6 Studies on therapeutic mechanisms........................................................ 6 1.7 Selection of clinical trial reports ............................................................... 7 2. Review of clinical trial reports............................................................................ 9 2.1 Pain ......................................................................................................... 9 Head and face.................................................................................................... 9 Locomotor system.............................................................................................. 9 Gout.................................................................................................................. 10 Biliary and renal colic ....................................................................................... 10 Traumatic or postoperative pain ...................................................................... 11 Dentistry ........................................................................................................... 11 Childbirth .......................................................................................................... 11 Surgery............................................................................................................. 11 2.2 Infections ............................................................................................... 12 2.3 Neurological disorders........................................................................... 12 2.4 Respiratory disorders............................................................................. 14 2.5 Digestive disorders ................................................................................ 14 2.6 Blood disorders...................................................................................... 15 2.7 Urogenital disorders............................................................................... 15 2.8 Gynaecological and obstetric disorders................................................. 16 v 2.9 Cardiovascular disorders....................................................................... 17 2.10 Psychiatric disorders and mental disturbances..................................... 18 2.11 Paediatric disorders .............................................................................. 19...
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