Celiac neuropathy Neurology

Ganglioside reactive antibodies in the neuropathy associated with celiac disease Armin Alaedini Department of Neurology and Neuroscience Cornell University, New York, NY Peter H.R. Green, MD Department of Medicine Columbia University, New York, NY Howard W. Sander Department of Neurology and Neuroscience Cornell University, New York, NY Arthur P. Hays Department of Pathology Columbia University, New York, NY Eugenia T. Gamboa Department of Neurology Columbia University, New York, NY Alessio Fasano Department of Pediatrics University of Maryland, Baltimore, MD Michelle

Sonnenberg Department of Neurology and Neuroscience Cornell University, New York, NY Lisa D. Lewis Department of Neurology Columbia University, New York, NY Norman Latov Department of Neurology and Neuroscience Cornell University, New York, NY This article was published in Journal of Neuroimmunology 127 (2002) pages 145-148, and is posted with permission from Elsevier. Single copies of this article can be downloaded and printed only for the reader’s personal research and study. Page 1 of 4 Abstract We tested patients with celiac disease (CD) for the presence of serum anti-ganglioside antibodies. Six of twenty-seven patient sera were reactive against brain gangliosides by an agglutination immunoassay. Neurological examination in all six revealed the presence of distal sensory loss, consistent with the diagnosis of peripheral neuropathy. When tested by ELISA for antibodies to isolated GM1, GM2, GD1a, GD1b, GT1b, and GQ1b ganglio- sides, all six were positive for IgG antibodies to at least one. The neuropathy of celiac disease may be autoimmune and associated with anti-ganglioside antibodies. The presence of IgG reactivity furthermore implicates a T cell-mediated response to ganglioside antigens. 1. Introduction Celiac disease (CD) is a chronic inflammatory enteropathy, me- diated by T-cell reactivity to ingested gluten proteins, resulting in villous...

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