Cytology of bronchial biopsy rinse fluid to improve the diagnostic

Eur Respir J 1998; 12: 1415–1418 DOI: 10.1183/09031936.98.12061415 Printed in UK - all rights reserved Copyright ©ERS Journals Ltd 1998 European Respiratory Journal ISSN 0903 - 1936 Cytology of bronchial biopsy rinse fluid to improve the diagnostic yield for lung cancer A. Rosell*, E. Monsó*, L. Lores*, X. Vilà*, M. Llatjós**, J. Ruiz*, J. Morera* aa Bronchoscopic techniques performed for the diagnosis of endobronchial lesions include bronchial biopsy and some accompanying cytological procedures such as needle aspiration and bronchial

washing or brushing. Some combinations of these techniques are reported to increase diagnostic yield for lung cancer [1–14]. Harvesting cellular debris shed from cytological or histology specimens has proven useful in some respiratory diagnostic procedures, such as trans- thoracic needle aspiration [15], bronchoscopic needle aspiration [16] and brushing [17, 18]. The saline solution used to rinse and handle the specimens in these procedures is cytologically examined. Examination of rinse fluid from bronchial biopsies, however, has only been mentioned once in the literature, in 1975 [4]. This study, therefore, tested the value of this apparently forgotten cytological technique, which can be used routinely whenever bronchial biopsies are performed and would, therefore, be cost-effective if shown to improve diagnostic yield. Materials and methods This study was carried out on 93 consecutive patients suspected of having pulmonary neoplasms who were referred to the authors' university hospital for bronchoscopy. Flexible bronchoscopy was performed transnasally with an Olympus 200 (Olympus, Tokyo, Japan) or a Pentax 15X (Pentax, Tokyo, Japan), under topical 2% lidocaine and i.v. midazolam (0.07 mg·kg -1 ) anaesthesia. All patients had single endobronchial lesions suspected of being malignant and were sampled with 2 mm Olympus alligator jaw for- ceps...

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